Male infertility and risk of cardiometabolic conditions: a population-based cohort study

Abstract

STUDY QUESTION Is male infertility independently associated with an increased risk of incident hypertension, ischemic and nonischemic heart disease, diabetes, and/or cerebrovascular disease? SUMMARY ANSWER Fathers diagnosed with male infertility have a modestly increased risk of heart disease, diabetes, and hypertension compared with fertile fathers, after controlling for measured confounders; however, some important confounders remain inadequately measured. WHAT IS KNOWN ALREADY Cohort studies suggest that infertile men have an increased risk of incident cardiometabolic diseases, including diabetes, hypertension, heart disease, and cerebrovascular disease, although findings are mixed. The r..